TP53 Mutations with Low Variant Allele Frequency Predict Short Survival in Chronic Lymphocytic Leukemia.
Riccardo BombenFrancesca Maria RossiFilippo VitTamara BittoloTiziana D'AgaroAntonella ZucchettoErika TissinoFederico PozzoElena VendraminiMassimo DeganEva ZainaIlaria CattarossiPaola VaraschinPaola NanniMichele BertonAlessandra BraidaJerry PoleselJared A CohenEnrico SantinelliAnnalisa BiagiMassimo GentileFortunato MorabitoGilberto FronzaGabriele PozzatoGiovanni D'ArenaJacopo OlivieriPietro BulianChristopher J PepperAnna HockadayAnna SchuhPeter HillmenDavide RossiAnnalisa ChiarenzaFrancesco ZajaFrancesco Di RaimondoGiovanni Del PoetaValter GatteiPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
TP53 mutations affected OS regardless of VAF. This finding can be used to update the definition of TP53 mutated CLL for clinical purposes.
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