Following a cohort of participants with MCI or mild dementia due to AD that mimics participants targeted for AD trials, this study showed slower decline in CDR-SB have significant effects on patients' work capacity and need for informal care, but not on their direct medical care utilization such as hospitalizations, ED use, and doctors' visits.Capturing potential benefits in health-related resource use may require direct measures of informal care and work/volunteer effort which are meaningful outcomes to patients, families and health systems.Caution is needed in our effort to assess benefits of recently developed disease modifying treatment in AD using electronic health records and administrative data from which utilization of direct medical care are routinely collected as these data sources may not capture the most apparent changes in resource utilization during early disease stages.
Keyphrases
- electronic health record
- end stage renal disease
- healthcare
- ejection fraction
- newly diagnosed
- palliative care
- emergency department
- peritoneal dialysis
- prognostic factors
- mild cognitive impairment
- computed tomography
- pain management
- metabolic syndrome
- adipose tissue
- quality improvement
- machine learning
- skeletal muscle
- risk assessment
- clinical decision support
- cognitive impairment
- patient reported outcomes
- drinking water
- adverse drug
- climate change
- chronic pain
- human health