IgA class-switched CD27-CD21+ B cells in IgA nephropathy.

Anna PopovaBaiba SlisereKarlis RacenisViktorija KuzemaRoberts KarklinsMikus SauliteJanis SeilisAnna Jana SauliteAiga VasilvolfaKristine VaivodeDace PjanovaJuta KroicaHarijs CernevskisAivars LejnieksAivars PetersonsKristine Oleinika

Published in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2024)

We propose that dysregulated immunity in the mucosa may drive de novo B cell activation within germinal centres, giving rise to IgAposCD27neg B cells and subsequently IgA-producing plasmablasts. These data integrate B cells into the paradigm of IgAN pathogenesis and allow to further investigate this pathway to uncover biomarkers and develop therapeutic interventions.

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