Circadian gene Rev-erbα influenced by sleep conduces to pregnancy by promoting endometrial decidualization via IL-6-PR-C/EBPβ axis.

Liyuan CuiFeng XuChunfang XuYan DingSongcun WangMei-Rong Du

Published in: Journal of biomedical science (2022)

Taken together, Rev-erbα regulated decidualization via IL-6-PR-C/EBPβ axis and might be a connector between sleep and pregnancy outcome. Therapies targeting Rev-erbα and IL-6 might help improving adverse pregnancy outcomes induced by sleep disturbance.

Keyphrases

pregnancy outcomes
pregnant women
sleep quality
physical activity
copy number
emergency department
cancer therapy
drug delivery