Association of Cardiovascular Health Through Young Adulthood With Genome-Wide DNA Methylation Patterns in Midlife: The CARDIA Study.

Yinan Zheng Brian Thomas Joyce Shih-Jen Hwang Jiantao MaLei LiuNorrina B AllenAmy E KrefmanJun WangTao GaoDrew R NanniniHaixiang ZhangDavid R JacobsMyron D GrossMyriam Fornage Cora Elizabeth Lewis Pamela J SchreinerStephen SidneyDongquan ChenPhilip Greenland Daniel LevyLifang HouDonald M Lloyd-Jones

Published in: Circulation (2022)

Cumulative CVH from young adulthood contributes to midlife epigenetic programming over time. Our findings demonstrate the role of epigenetic markers in response to CVH changes and highlight the potential of epigenomic markers for precision CVD prevention, and earlier detection of subclinical CVD, as well.

Keyphrases

dna methylation
genome wide
gene expression
depressive symptoms
middle aged
copy number
loop mediated isothermal amplification
human health
climate change
quantum dots
real time pcr