The LDL/HDL ratio predicts long-term risk of coronary revascularization in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention: a cohort study.
Ruochen ZhangYan FanYanbo XueYunfei FengCaijuan DongYamei WangPuqing KouGuoli LiAiqun MaTingzhong WangPublished in: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas (2022)
Clinical indicators do not adequately predict the long-term prognosis of patients with ST-segment elevation myocardial infarction (STEMI) following percutaneous coronary intervention (PCI). The low-density lipoprotein (LDL)/high-density lipoprotein (HDL) ratio is expected to be a reliable predictor of the long-term prognosis of these patients. This study aimed to explore the correlation between the LDL/HDL ratio and long-term prognosis in STEMI patients undergoing PCI. Patients with confirmed STEMI who underwent PCI in 7 hospitals in China from January 2009 to December 2011 were enrolled. Information about clinical endpoints, including all-cause death and major adverse cardiovascular events, was collected. Overall, 915 patients were included for analysis, the average follow-up time was 112.2 months. According to the LDL/HDL ratio, the patients were divided into 3 groups using the three-quantile method: low (LDL/HDL≤1.963), medium (1.963<LDL/HDL<2.595), and high (LDL/HDL≥2.595) LDL/HDL groups. The rate of coronary revascularization was higher in the high LDL/HDL group (28.52%) than in the low (17.38%, P=0.001) and medium (19.34%, P=0.010) LDL/HDL groups. The hazard ratio of coronary revascularization was significantly higher in the high LDL/HDL group than in the low (P=0.007) and medium (P=0.004) LDL/HDL groups. Increased LDL/HDL ratio was an independent risk factor for long-term coronary revascularization in STEMI patients undergoing PCI (HR=1.231, 95%CI: 1.023-1.482, P=0.028). These findings suggest that an increased LDL/HDL ratio was an independent risk factor for long-term coronary revascularization in STEMI patients undergoing PCI. The risk of coronary revascularization was significantly increased in patients with LDL/HDL≥2.595.
Keyphrases
- percutaneous coronary intervention
- st segment elevation myocardial infarction
- coronary artery disease
- low density lipoprotein
- st elevation myocardial infarction
- acute myocardial infarction
- coronary artery bypass grafting
- antiplatelet therapy
- acute coronary syndrome
- cardiovascular events
- patients undergoing
- end stage renal disease
- coronary artery
- coronary artery bypass
- atrial fibrillation
- ejection fraction
- chronic kidney disease
- newly diagnosed
- prognostic factors
- high density
- patient reported outcomes
- type diabetes
- aortic stenosis
- peritoneal dialysis
- emergency department
- patient reported