The Legacy Effect in Treating Hypercholesterolemia.
John B KostisMrinali ShettyYuvraj Singh ChowdhuryWilliam J KostisPublished in: Journal of cardiovascular pharmacology and therapeutics (2020)
The legacy effect results in significant long-term clinical benefits by preventing fatal and nonfatal events. This implies that early therapy would result in lower event rates. Long-term follow-up should be a part of clinical trial design in order to evaluate the presence or absence of a legacy effect.