Long-term risk associated with clonal hematopoiesis in patients with severe aortic valve stenosis undergoing TAVR.
Silvia Mas-PeiroGraziella PergolaAlexander BerkowitschManja MeggendorferMichael A RiegerMariuca Vasa-NicoteraStefanie DimmelerAndreas M ZeiherPublished in: Clinical research in cardiology : official journal of the German Cardiac Society (2023)
DNMT3A- and TET2-CHIP-driver mutations are associated with long-term mortality in patients with aortic valve stenosis even after a successful TAVR. The association is also present in never smokers, in whom no biasing effect from smoking on DNA methylation is to be expected.
Keyphrases
- aortic valve
- dna methylation
- transcatheter aortic valve replacement
- aortic stenosis
- transcatheter aortic valve implantation
- aortic valve replacement
- smoking cessation
- genome wide
- gene expression
- cardiovascular events
- early onset
- high throughput
- type diabetes
- cardiovascular disease
- single cell
- atrial fibrillation
- hematopoietic stem cell