Real-time analysis of Pd2(dba)3 activation by phosphine ligands.
Eric JanussonHarmen S ZijlstraPeter P T NguyenLandon MacGillivrayJulio MartelinoJ Scott McIndoePublished in: Chemical communications (Cambridge, England) (2018)
A combination of UV-Vis spectroscopy and electrospray ionization mass spectrometry is used for real-time monitoring of Pd2(dba)3 activation with sulfonated versions of PPh3 and Buchwald-type ligands. This provides insight into the effect of ligand and preparation conditions on activation and allows for establishment of rational activation protocols.