Synthesis of 3-Fluoroindoles via Photoredox Catalysis.

Liubov I PanferovaVladimir O SmirnovVitalij V LevinVladimir A KokorekinMarina I StruchkovaAlexander D Dilman

Published in: The Journal of organic chemistry (2016)

A method for the synthesis of 3-fluoroindoles from N-arylamines substituted with the CF2I group is described. The reaction is mediated by a ruthenium photocatalyst in the presence of a substoichiometric amount of triphenylphosphine upon irradiation with blue light. The starting N-arylamines are readily obtained by nucleophilic iododifluoromethylation of iminium ions.

Keyphrases

visible light
cystic fibrosis
quantum dots
highly efficient
molecular dynamics simulations
electron transfer