Cucurbitacin B inhibits TGF-β1-induced epithelial-mesenchymal transition (EMT) in NSCLC through regulating ROS and PI3K/Akt/mTOR pathways.
Renyikun YuanQiumei FanXiaowei LiangShan HanJia HeQin-Qin WangHongwei GaoYulin FengShilin YangPublished in: Chinese medicine (2022)
CuB inhibits EMT in TGF-β1-induced A549 cells and Gefitinib resistant A549 cells through decreasing ROS production and PI3K/Akt/mTOR signaling pathway. In vivo study validated that CuB inhibits lung cancer metastasis in mice. The study may be supporting CuB as a promising therapeutic agent for NSCLC and Gefitinib resistant NSCLC.
Keyphrases
- epithelial mesenchymal transition
- small cell lung cancer
- induced apoptosis
- transforming growth factor
- signaling pathway
- cell cycle arrest
- cell death
- advanced non small cell lung cancer
- high glucose
- diabetic rats
- dna damage
- epidermal growth factor receptor
- reactive oxygen species
- endoplasmic reticulum stress
- drug induced
- oxidative stress
- skeletal muscle
- endothelial cells
- wild type