Heart rate elevations during early sepsis predict death in fluid-resuscitated rats with fecal peritonitis.
Alain RudigerVictor JegerMattia ArrigoChristian A SchaerFlorian F HildenbrandMargarete ArrasBurkhardt SeifertMervyn SingerGabriele SchoedonDonat R SpahnDominique BettexPublished in: Intensive care medicine experimental (2018)
In this long-term rat sepsis model, prognostication could be made early by telemetry-monitored changes in heart rate. This model enables the study of underlying mechanisms and the assessment of any differential effects of novel therapies in predicted survivors or non-survivors.