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Heart rate elevations during early sepsis predict death in fluid-resuscitated rats with fecal peritonitis.

Alain RudigerVictor JegerMattia ArrigoChristian A SchaerFlorian F HildenbrandMargarete ArrasBurkhardt SeifertMervyn SingerGabriele SchoedonDonat R SpahnDominique Bettex
Published in: Intensive care medicine experimental (2018)
In this long-term rat sepsis model, prognostication could be made early by telemetry-monitored changes in heart rate. This model enables the study of underlying mechanisms and the assessment of any differential effects of novel therapies in predicted survivors or non-survivors.
Keyphrases
  • heart rate
  • heart rate variability
  • blood pressure
  • acute kidney injury
  • intensive care unit
  • young adults
  • septic shock
  • cardiac arrest
  • oxidative stress