Heart rate elevations during early sepsis predict death in fluid-resuscitated rats with fecal peritonitis.

Alain RudigerVictor JegerMattia ArrigoChristian A SchaerFlorian F HildenbrandMargarete ArrasBurkhardt SeifertMervyn SingerGabriele SchoedonDonat R SpahnDominique Bettex

Published in: Intensive care medicine experimental (2018)

In this long-term rat sepsis model, prognostication could be made early by telemetry-monitored changes in heart rate. This model enables the study of underlying mechanisms and the assessment of any differential effects of novel therapies in predicted survivors or non-survivors.

Keyphrases

heart rate
heart rate variability
blood pressure
acute kidney injury
intensive care unit
young adults
septic shock
cardiac arrest
oxidative stress