Early Life Stress in Mice Leads to Impaired Colonic Corticosterone Production and Prolonged Inflammation Following Induction of Colitis.

Rachel Q MuirBarbara J KlockeMelissa S JenningsPatrick A MolinaJung-Shan HsuCailin E KellumKatie L AlexanderGoo LeeJeremy B FooteRobin G LorenzJennifer S PollockCraig L Maynard

Published in: Inflammatory bowel diseases (2023)

Our study identifies impaired local glucocorticoid production and responsiveness as a potential mechanism whereby ELS predisposes to chronic colitis in susceptible hosts.

Keyphrases

early life
ulcerative colitis
oxidative stress
genome wide
gene expression
risk assessment
human health
adipose tissue
stress induced