Frailty effects on non-demented cognitive trajectories are moderated by sex and Alzheimer's genetic risk.

Sherilyn ThibeauKirstie McDermottG Peggy McFallKenneth RockwoodRoger A Dixon

Published in: Alzheimer's research & therapy (2019)

In non-demented older adults, increasing frailty is strongly associated with the differential decline in cognitive trajectories. For example, higher (worse) frailty was associated with more rapid memory decline than was lower (better) frailty. These effects, however, are moderated by both genetic risk and sex.

Keyphrases

community dwelling
depressive symptoms
genome wide
copy number
physical activity
working memory
gene expression