Longitudinal assessment of sputum microbiome by sequencing of the 16S rRNA gene in non-cystic fibrosis bronchiectasis patients.
Michael J CoxElena M TurekCatherine HennessyGhazala K MirzaPhillip L JamesMeg ColemanAndrew JonesRobert WilsonDiana BiltonWilliam O C CooksonMiriam F MoffattMichael R LoebingerPublished in: PloS one (2017)
The use of microbial community analysis of sputum added to information from microbial culture. A simple model of exacerbations driven by bacterial overgrowth was not supported, suggesting a need for revision of principles for antibiotic therapy. In individual patients, the management of chronic bronchial infection may be improved by therapy specific to their microbiome, taking into account pathogen load, community stability, and acute and chronic community responses to antibiotics.
Keyphrases
- cystic fibrosis
- microbial community
- end stage renal disease
- ejection fraction
- healthcare
- pseudomonas aeruginosa
- chronic kidney disease
- mental health
- mycobacterium tuberculosis
- prognostic factors
- peritoneal dialysis
- chronic obstructive pulmonary disease
- drug induced
- liver failure
- gene expression
- patient reported outcomes
- genome wide
- transcription factor
- dna methylation
- extracorporeal membrane oxygenation
- mesenchymal stem cells
- acute respiratory distress syndrome