The use of pseudo-MRM for a sensitive and selective detection and quantification of polycyclic aromatic compounds by tandem mass spectrometry.
Mathieu GalmicheAnaïs RodriguesEstelle MotschOlivier DelhommeYannis Nicolas FrançoisMaurice MilletPublished in: Rapid communications in mass spectrometry : RCM (2022)
The results of this study show an important gain in sensitivity when using pseudo-MRM instead of MRM for non-polar PACs on QqQ instruments. The selectivity of MRM is preserved in pseudo-MRM by applying non-zero collision energies to which only these non-polar PACs are resistant, not the isobaric interferences. No interference issue was observed when analyzing Diesel PM, a complex matrix, with our pseudo-MRM method. Therefore, we advise for a broader use of this MS/MS mode for trace-level determination of non-polar PAHs.
Keyphrases
- tandem mass spectrometry
- ms ms
- ultra high performance liquid chromatography
- heavy metals
- high performance liquid chromatography
- particulate matter
- solid phase extraction
- simultaneous determination
- liquid chromatography
- air pollution
- liquid chromatography tandem mass spectrometry
- high resolution
- mass spectrometry
- density functional theory
- health risk assessment
- human health
- structural basis
- quantum dots