Time to abandon ampicillin plus gentamicin in favour of ampicillin plus ceftriaxone in Enterococcus faecalis infective endocarditis? A meta-analysis of comparative trials.
Moritz MirnaAlbert TopfLukas SchmutzlerUta C HoppeMichael LichtenauerPublished in: Clinical research in cardiology : official journal of the German Cardiac Society (2021)
Treatment with AC was non-inferior to treatment with AG, and it was associated with a reduced prevalence of nephrotoxicity and drug withdrawal due to adverse events. Thus, combination therapy with AC appears favourable over AG in patients with E. faecalis IE.