Anti-HER2 therapy for breast cancer in older patients.
Marcelle Goldner CescaMaria Alice B FranzoiLissandra D LagoNoam PondéPublished in: Future oncology (London, England) (2020)
Older patients now form between 30 and 40% of breast cancer (BC) patients. Managing older patients with BC is particularly challenging due to the limited availability of high-quality evidence. In this review we discuss the available evidence on the efficacy and safety of anti-HER2 agents in older patients with HER2-positive BC is presented, with a particular look at the latest results of promising new agents such trastuzumab-deruxtecan. The data suggest that older patients can expect similar efficacy when using standard regimens, with higher toxicity, particular cardiac toxicity and diarrhea. Anti-HER2 agents should thus be used in most older patients most as per standard of care as long as adequate follow-up is available to manage toxicities.
Keyphrases
- end stage renal disease
- ejection fraction
- healthcare
- oxidative stress
- physical activity
- newly diagnosed
- community dwelling
- middle aged
- palliative care
- peritoneal dialysis
- left ventricular
- prognostic factors
- heart failure
- big data
- pain management
- young adults
- machine learning
- clostridium difficile
- deep learning
- tyrosine kinase