Login / Signup

UBE2L3 Promotes Oxidative Stress-regulated Necroptosis to Accelerate Osteosarcoma Progression.

Xiwu ZhaoGuoqiang ShanDeguo XingHongwei GaoZhenggang XiongWenpeng HuiMingzhi Gong
Published in: Recent patents on anti-cancer drug discovery (2024)
UBE2L3 is upregulated in osteosarcoma cells, and silencing of UBE2L3 promotes oxidative stress in these cells, leading to enhanced necroptosis and delayed progression of osteosarcoma.
Keyphrases
  • induced apoptosis
  • oxidative stress
  • cell cycle arrest
  • endoplasmic reticulum stress
  • signaling pathway
  • dna damage
  • cell death
  • pi k akt