Observational cohort study of neurological involvement among patients with SARS-CoV-2 infection.
Michael FleischerMartin KöhrmannSebastian DolffFabian SzepanowskiKarsten SchmidtFrank HerbstreitCansu GüngörBenjamin StolteKatharina Marie SteinerChristine StadtlerJoachim RißeMelanie FiedlerGerd Meyer Zu HörsteAnne-K MausbergClemens KillMichael ForstingUlrich SureUlf DittmerOliver WitzkeThorsten BrennerChristoph KleinschnitzMark StettnerPublished in: Therapeutic advances in neurological disorders (2021)
Cerebrovascular events were the most frequent severe NIV and severe NIV was associated with high mortality. Incidence of NIV increased with respiratory symptoms and NIV and pre-existing neurological morbidities were independent risk factors for fatality. Inflammatory involvement due to BBB disruption and cytokine release drives NIV, rather than direct viral invasion. These findings might help physicians define a further patient group requiring particular attention during the pandemic.