Login / Signup

Association of Cognitive Impairment With Free Water in the Nucleus Basalis of Meynert and Locus Coeruleus to Transentorhinal Cortex Tract.

Winston Thomas ChuWei-En WangLaszlo ZaborszkyTodd Eliot GoldeSteven DeKoskyRanjan DuaraDavid A LoewensteinMalek AdjouadiStephen A CoombesDavid E Vaillancourt
Published in: Neurology (2021)
These results show that higher FW is associated with greater clinical diagnosis severity, cognitive impairment, and neurofilament light chain. They also suggest that FW elevation occurs in the locus coeruleus to transentorhinal cortex tract, nucleus basalis of Meynert, and hippocampus in the transition from CN to EMCI, while other basal forebrain regions and the entorhinal cortex are not affected until a later stage of AD. FW is a clinically relevant and noninvasive early marker of structural changes related to cognitive impairment.
Keyphrases
  • cognitive impairment
  • functional connectivity
  • genome wide association study
  • cerebrospinal fluid
  • lymph node metastasis
  • squamous cell carcinoma