Multiple large osteolytic lesions in a patient with systemic mastocytosis: a challenging diagnosis.

Massimiliano BonifacioRoberta ZanottiEmanuele GuardalbenElda MimiolaFrancesca ScognamiglioOmar PerbelliniGiovanna De MatteisLuis EscribanoPatrizia BonadonnaDaniela GrigolatoSergio BissoliAlice ParisiAlberto ZamòAchille AmbrosettiMaurizio Rossini

Published in: Clinical case reports (2017)

Patients with advanced variants of Systemic Mastocytosis may develop destructive bone lesions when massive mast cell (MC) infiltrates are present. Finding of large osteolyses in indolent systemic mastocytosis, typically characterized by low MC burden, should prompt investigations for an alternative explanation.

Keyphrases

copy number
gene expression
drug induced
dna methylation
hodgkin lymphoma