Immune Recognition of Citrullinated Proteoglycan Aggrecan Epitopes in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis.
Adrienn MarkovicsTímea OcskóRobert S KatzEdit I BuzásTibor T GlantKatalin MikeczPublished in: PloS one (2016)
We identified a novel citrullinated PG epitope (Cit49) that is highly immunogenic in mice with PGIA and in RA patients. We also describe T-cell and antibody reactivity with Cit49 in ACPA+ RA. As citrullinated PG might be present in RA articular cartilage, Cit PG epitope-induced T-cell activation or antibody deposition may occur in the joints of RA patients.
Keyphrases
- rheumatoid arthritis
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- disease activity
- high glucose
- ankylosing spondylitis
- type diabetes
- patient reported outcomes
- systemic lupus erythematosus
- oxidative stress
- high fat diet induced
- drug induced
- systemic sclerosis
- adipose tissue
- stress induced
- wild type