A SREBF2-dependent gene program drives an immunotolerant dendritic cell population during cancer progression.

Michael P PlebanekYue XueY-Van NguyenNicholas C DeVitoXueying WangAlisha HoltzhausenGeorgia M BeasleyNagendra YarlaBala ThievanthiranBrent A Hanks

Published in: bioRxiv : the preprint server for biology (2023)

The metabolic transcription factor, SREBF2, regulates the development and tolerogenic function of the mregDC population within the tumor microenvironment.

Keyphrases

dendritic cells
transcription factor
regulatory t cells
quality improvement
papillary thyroid
immune response
squamous cell carcinoma
squamous cell
gene expression
copy number
young adults
genome wide analysis