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A SREBF2-dependent gene program drives an immunotolerant dendritic cell population during cancer progression.

Michael P PlebanekYue XueY-Van NguyenNicholas C DeVitoXueying WangAlisha HoltzhausenGeorgia M BeasleyNagendra YarlaBala ThievanthiranBrent A Hanks
Published in: bioRxiv : the preprint server for biology (2023)
The metabolic transcription factor, SREBF2, regulates the development and tolerogenic function of the mregDC population within the tumor microenvironment.
Keyphrases
  • dendritic cells
  • transcription factor
  • regulatory t cells
  • quality improvement
  • papillary thyroid
  • immune response
  • squamous cell carcinoma
  • squamous cell
  • gene expression
  • copy number
  • young adults
  • genome wide analysis