A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy.
Eduardo Guimarães VieiraRodrigo Boni FazziDaniel O T A MartinsAlena M ShevelevaFloriana TunaAna Maria da Costa FerreiraPublished in: RSC advances (2023)
A novel strategy of improving cytotoxicity against metastatic melanoma cells using an oxindolimine copper(ii) complex immobilized and dimerized on a modified Polyhedral Oligomeric Silsesquioxane (POSS) matrix was developed, as revealed by electron paramagnetic resonance (EPR) spectroscopy. An assured correlation between continuous-wave (CW) and pulsed EPR spectroscopies provided a complete characterization of the actual active species, its coordination environment, as well as the efficiency/selectivity of the bioconjugate materials.
Keyphrases
- induced apoptosis
- single molecule
- high resolution
- cell cycle arrest
- small cell lung cancer
- squamous cell carcinoma
- oxide nanoparticles
- solid state
- energy transfer
- oxidative stress
- cell death
- endoplasmic reticulum stress
- cell proliferation
- mass spectrometry
- signaling pathway
- pi k akt
- structural basis
- electron microscopy