GCH1 variants contribute to the risk and earlier age-at-onset of Parkinson's disease: a two-cohort case-control study.
Hong-Xu PanYu-Wen ZhaoJun-Pu MeiZheng-Huan FangYige WangXun ZhouYang-Jie ZhouRui ZhangKai-Lin ZhangLi JiangQian ZengYan HeZheng WangZhen-Hua LiuQian XuQi-Ying SunYang YangYa-Cen HuYa-Se ChenJuan DuLi-Fang LeiHai-Nan ZhangChun-Yu WangXin-Xiang YanLu ShenHong JiangJie-Qiong TanJin-Chen LiBei-Sha TangJi-Feng GuoPublished in: Translational neurodegeneration (2020)
The results highlight the importance of deleterious variants and non-coding variants of GCH1 in PD in Chinese mainland and suggest that GCH1 mutation can influence the PD phenotype, which may help design experimental studies to elucidate the mechanisms of GCH1 in the pathogenesis of PD.