Macrophages can secrete exosomes containing miR-223 and promote apoptosis by targeting the IGF-1R/Akt/mTOR signaling pathway in A549 cells and mouse models, suggesting that miR-223 is a potential target for treating COVID-19 induced ARDS.
Keyphrases
- cell proliferation
- pi k akt
- cell cycle arrest
- signaling pathway
- long non coding rna
- induced apoptosis
- long noncoding rna
- acute respiratory distress syndrome
- endoplasmic reticulum stress
- coronavirus disease
- extracorporeal membrane oxygenation
- oxidative stress
- mechanical ventilation
- mouse model
- sars cov
- mesenchymal stem cells
- cell death
- stem cells
- cell therapy
- diabetic rats
- high glucose
- intensive care unit
- growth hormone
- endothelial cells
- bone marrow
- respiratory syndrome coronavirus