Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes.
Christine P LimonteErkka ValoViktor DrelLoki NatarajanManjula DarshiCarol ForsblomClark M HendersonAndrew N HoofnagleWenjun JuMatthias KretzlerDaniel MontemayorViji NairRobert G NelsonJohn F O'TooleRobert D TotoSylvia E RosasJohn RuzinskiErkka ValoInsa M SchmidtTomas VaisarSushrut S WaikarJing ZhangEllen BurgessTarunveer S AhluwaliaPer-Henrik GroopSubramaniam PennathurJanet K Snell-BergeonTina CostacouTrevor J OrchardKumar SharmaIan H de Boernull nullPublished in: Diabetes care (2022)
Urine cathepsin D is associated with rapid eGFR decline in T1D and reflects kidney tubulointerstitial injury.