The causal relationship between gastro-esophageal reflux disease and idiopathic pulmonary fibrosis: A bidirectional two-sample Mendelian randomization study.
Carl J ReynoldsFabiola Del Greco MRichard J AllenCarlos FloresR Gisli JenkinsToby M MaherPhilip L MolyneauxImre NothJustin M OldhamLouise V WainJiyuan AnJue-Sheng OngStuart MacGregorTom A YatesPaul CullinanCosetta MinelliPublished in: The European respiratory journal (2023)
We found that GERD increases the risk of IPF, but found no evidence that IPF increases the risk of GERD. GERD should be considered in future studies of IPF risk, and interest in it as a potential therapeutic target should be renewed. The mechanisms underlying the effect of GERD on IPF should also be investigated.