Molecular basis underlying changes of brain entropy and functional connectivity in major depressive disorders after electroconvulsive therapy.
Xiaohui YuKexuan ChenYingzi MaTongjian BaiShunli ZhuDefang CaiXing ZhangKai WangYuanghua TianJiaojian WangPublished in: CNS neuroscience & therapeutics (2024)
Compared to pretreatment, the BEN in the posterior cerebellar lobe (PCL) significantly decreased and FC between the PCL and the right temporal pole (TP) significantly increased in MDD patients after treatment. Moreover, we found that these changes of BEN and FC were closely associated with genes' expression profiles involved in MAPK signaling pathway, GABAergic synapse, and dopaminergic synapse and were significantly correlated with the receptor/transporter density of 5-HT, norepinephrine, glutamate, etc. CONCLUSION: These findings suggest that loops in the cerebellum and TP are crucial for ECT regulation of mood and cognition, which provides new evidence for the antidepressant effects of ECT and the potential molecular mechanism leading to cognitive impairment.
Keyphrases
- functional connectivity
- resting state
- signaling pathway
- major depressive disorder
- cognitive impairment
- end stage renal disease
- bipolar disorder
- pi k akt
- newly diagnosed
- ejection fraction
- white matter
- chronic kidney disease
- peritoneal dialysis
- genome wide
- dna methylation
- depressive symptoms
- mild cognitive impairment
- induced apoptosis
- transcription factor
- patient reported outcomes
- stress induced
- binding protein
- subarachnoid hemorrhage
- bioinformatics analysis
- climate change