Login / Signup

Off-target effects of oral anticoagulants - vascular effects of vitamin K antagonist and non-vitamin K antagonist oral anticoagulant dabigatran etexilate.

Rick H van GorpIngrid DijkgraafVanessa BrökerMatthias BauwensPeter LeendersDanyel JennenMarc R DweckJan BuceriusJacco J BriedéJoanne van RynVincent BrandenburgFelix MottaghyHenri M H SpronkChris P ReutelingspergerLeon J Schurgers
Published in: Journal of thrombosis and haemostasis : JTH (2021)
Warfarin aggravates atherosclerotic disease activity, increasing plaque inflammation, active calcification, and plaque progression. Dabigatran lacks undesired vascular side effects and reveals beneficial effects on atherosclerosis progression and calcification. The choice of anticoagulation impacts atherosclerotic disease by differential off target effect. Future clinical studies should test whether this beneficial effect also applies to patients.
Keyphrases