Lp-PLA2, scavenger receptor class B type I gene (SCARB1) rs10846744 variant, and cardiovascular disease.

Ani ManichaikulXin-Qun WangLi LiJeanette ErdmannGuillaume LettreJoshua C BisDawn WaterworthMary CushmanNancy S JennyWendy S PostWalter PalmasMichael Y TsaiLars WallentinHarvey WhiteHeribert SchunkertChristopher J O'DonnellDavid M HerringtonStephen S RichMichelle L O'DonoghueAnnabelle Rodriguez

Published in: PloS one (2018)

SCARB1 rs10846744 is significantly associated with Lp-PLA2 activity, atherosclerosis, and CVD events, but Lp-PLA2 activity is not a mediator in the association of rs10846744 with cIMT in MESA.

Keyphrases

cardiovascular disease
copy number
gene expression
coronary artery disease
binding protein
transcription factor