Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.
null nullnull nullnull nullEwan C GoligherCharlotte Ann BradburyBryan J McVerryPatrick R LawlerJeffrey S BergerMichelle N GongMarc CarrierHarmony R ReynoldsAnand KumarAlexis F TurgeonLucy Z KornblithSusan R KahnJohn C MarshallKeri S KimBrett L HoustonLennie P G DerdeAndrea N EdgintonTobias TritschlerDerek C AngusLucas Colombo GodoyZoe McQuiltenBridget-Anne KirwanMichael E FarkouhMaria M BrooksRoger J LewisLindsay R BerryElizabeth LorenziAnthony C GordonTania AhujaFarah Al-BeidhDjillali AnnaneYaseen M ArabiDiptesh AryalLisa Baumann KreuzigerAbigail BeaneZahra BhimaniShailesh BihariHenny H BillettLindsay BondMarc BontenFrank BrunkhorstMeredith BuxtonAdrian BuzgauLana A CastellucciSweta ChekuriJen-Ting ChenAllen C ChengTamta ChkhikvadzeBenjamin CoiffardAira ContrerasTodd W CostantiniSophie de BrouwerMichelle A DetryAbhijit DuggalVladimír DžavíkMark B EffronHeather F EngJorge EscobedoLise J EstcourtBrendan M EverettDean A FergussonMark FitzgeraldRobert A FowlerJoshua D FroessZhuxuan FuJean P GalanaudBenjamin T GalenSheetal GandotraTimothy D GirardAndrew L GoodmanHerman GoossensCameron GreenYonatan Y GreensteinPeter L GrossRashan HaniffaSheila M HegdeCarolyn M HendricksonAlisa M HigginsAlexander A HindenburgAluko A HopeJames M HorowitzChristopher M HorvatDavid T HuangKristin HudockBeverley J HuntMansoor HusainRobert C HyzyJeffrey R JacobsonDevachandran JayakumarNorma M KellerAkram KhanYuri KimAndrei KindzelskiAndrew J KingM Margaret KnudsonAaron E KornblithMatthew E KutcherMichael A LaffanFrancois LamontagneGrégoire Le GalChristine M LeeperEric S LeiferGeorge LimFelipe Gallego LimaKelsey LinstrumEdward LittonJose Lopez-SendonSylvain A LotherNicole MartenAndréa Saud MarinezMary MartinezEduardo Mateos GarciaStavroula MavromichalisDaniel F McAuleyEmily G McDonaldAnna McGlothlinShay P McGuinnessSaskia MiddeldorpStephanie K MontgomeryPaul R MounceySrinivas MurthyGirish B NairRahul NairAlistair D NicholJose C NicolauBrenda Nunez-GarciaJohn J ParkPauline K ParkRachael L ParkeJane C ParkerSam ParniaJonathan D PaulMauricio PompilioJohn G QuigleyRobert S RosensonNatalia S RostKathryn RowanFernanda O SantosMarlene SantosMayler O SantosLewis SatterwhiteChristina T SaundersJake SchreiberRoger E G SchutgensChristopher W SeymourDeborah M SiegalDelcio G SilvaAneesh B SinghalArthur S SlutskyDayna SolvasonSimon J StanworthAnne M TurnerWilma van Bentum-PuijkFrank L van de VeerdonkSean van DiepenGloria Vazquez-GrandeLana WahidVanessa WarehamR Jay WidmerJennifer G WilsonEugene YuriditskyYongqi ZhongScott M BerryColin J McArthurMatthew D NealJudith S HochmanSteven A WebbRyan ZarychanskiPublished in: The New England journal of medicine (2021)
In critically ill patients with Covid-19, an initial strategy of therapeutic-dose anticoagulation with heparin did not result in a greater probability of survival to hospital discharge or a greater number of days free of cardiovascular or respiratory organ support than did usual-care pharmacologic thromboprophylaxis. (REMAP-CAP, ACTIV-4a, and ATTACC ClinicalTrials.gov numbers, NCT02735707, NCT04505774, NCT04359277, and NCT04372589.).