Inhibition of EZH2 and activation of ERRγ synergistically suppresses gastric cancer by inhibiting FOXM1 signaling pathway.

Boyan HuangPeiqiang MuYan YuWenya ZhuTianqing JiangRong DengGongkan FengJikai WenXiaofeng ZhuYiqun Deng

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2020)

The FOXM1 signaling pathway underlying the ERRγ-mediated gastric cancer suppression was identified. Furthermore, combined treatment with EZH2 inhibitor and ERRγ agonist synergistically suppressed GC progression by inhibiting this signaling pathway, suggesting its high potential in treating GC patients.

Keyphrases

signaling pathway
pi k akt
induced apoptosis
epithelial mesenchymal transition
end stage renal disease
ejection fraction
chronic kidney disease
long non coding rna
long noncoding rna
risk assessment
patient reported outcomes
human health
climate change
simultaneous determination