Progressive APOBEC3B mRNA expression in distant breast cancer metastases.
Anieta M SieuwertsWillemijne A M E SchrijverSimone U DalmVanja de WeerdCathy B MoelansNatalie Ter HoevePaul J van DiestJohn W M MartensCarolien H M van DeurzenPublished in: PloS one (2017)
APOBEC3B mRNA levels are significantly higher in breast cancer metastases as compared to the corresponding ER-positive primary tumors. This suggests a potential role for APOBEC3B in luminal breast cancer progression, and consequently, a promising role for anti-APOBEC3B therapies in advanced stages of this frequent form of breast cancer.