Hydroxychloroquine blood levels predicts flare in childhood-onset lupus nephritis.
Verena Andrade BalbiClovis Artur Almeida da SilvaTatiana Nascimento PedrosaRosa Maria Rodrigues PereiraLucia Maria de Arruda CamposElaine Pires LeonNilo DuarteValdemir Melechco CarvalhoSandra Gofinet PasotoDebora Cordeiro do RosárioLeticia Kolachinski BrandaoHermine I BrunnerEloisa S BonfaNádia Emi AikawaPublished in: Lupus (2021)
We demonstrated that HCQ blood cut-off level under 1075 ng/mL predicts flare in childhood-onset LN patients under prescribed HCQ dose of 4.0-5.5 mg/kg/day. We further observed that most of these patients have compliance issues reinforcing the need for a close surveillance particularly in those with levels below the defined cut-off.