Relevance of PD-L1 Non-Coding Polymorphisms on the Prognosis of a Genetically Admixed NSCLC Cohort.

Juliana Rodrigues Machado Rúgolo Tabatha Gutierrez Prieto Alexandre Todorovic FabroEdwin Roger Parra CuentasVanessa Karen Sá Camila Machado Baldavira Cláudia Aparecida Rainho Erick da Cruz CastelliCecilia FarhatTeresa Yae Takagaki Maria Aparecida Nagai Vera Luiza Capelozzi

Published in: Pharmacogenomics and personalized medicine (2021)

PD-L1 non-coding variants play an important role in modulating immune checkpoint function and may be explored as immunotherapy biomarkers. We highlight the rs7041009 variant, which impacts OS and PPS in NSCLC patients.

Keyphrases

small cell lung cancer
end stage renal disease
ejection fraction
newly diagnosed
advanced non small cell lung cancer
chronic kidney disease
peritoneal dialysis
prognostic factors
gene expression
copy number