Patient-derived organoids of bladder cancer recapitulate antigen expression profiles and serve as a personal evaluation model for CAR-T cells in vitro.
Lei YuZhichao LiHongbin MeiWujiao LiDong ChenLisa LiuZhongfu ZhangYangyang SunFei SongWei ChenWeiren HuangPublished in: Clinical & translational immunology (2021)
Patient-derived BCOs recapitulate the heterogeneity and key features of parental cancer tissues, and these BCOs could be useful for preclinical testing of CAR-T cells in vitro.