Patient-derived organoids of bladder cancer recapitulate antigen expression profiles and serve as a personal evaluation model for CAR-T cells in vitro.

Lei YuZhichao LiHongbin MeiWujiao LiDong ChenLisa LiuZhongfu ZhangYangyang SunFei SongWei ChenWeiren Huang

Published in: Clinical & translational immunology (2021)

Patient-derived BCOs recapitulate the heterogeneity and key features of parental cancer tissues, and these BCOs could be useful for preclinical testing of CAR-T cells in vitro.

Keyphrases

papillary thyroid
squamous cell
gene expression
single cell
cell therapy
lymph node metastasis
squamous cell carcinoma
stem cells
bone marrow
young adults