Epigenetics in Heart Failure: Role of DNA Methylation in Potential Pathways Leading to Heart Failure with Preserved Ejection Fraction.
Simon W RabkinChenille N WongPublished in: Biomedicines (2023)
This review will focus on epigenetic modifications utilizing the DNA methylation mechanism, which is potentially involved in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). The putative pathways of HFpEF will be discussed, specifically myocardial fibrosis, myocardial inflammation, sarcoplasmic reticulum Ca 2+ -ATPase, oxidative-nitrosative stress, mitochondrial and metabolic defects, as well as obesity. The relationship of HFpEF to aging and atrial fibrillation will be examined from the perspective of DNA methylation.
Keyphrases
- dna methylation
- heart failure
- genome wide
- atrial fibrillation
- gene expression
- left ventricular
- oxidative stress
- insulin resistance
- metabolic syndrome
- type diabetes
- left atrial
- weight loss
- copy number
- skeletal muscle
- left atrial appendage
- physical activity
- oral anticoagulants
- acute coronary syndrome
- percutaneous coronary intervention
- body mass index
- liver fibrosis
- human health
- protein kinase