RNA-induced epigenetic silencing inhibits HIV-1 reactivation from latency.
Catalina MéndezScott LedgerKathy PetoumenosChantelle L AhlenstielAnthony D KelleherPublished in: Retrovirology (2018)
The active maintenance of epigenetic silencing by shRNAs acting on the HIV-1 LTR impedes HIV-1 reactivation from latency. Our "block and lock" approach constitutes a novel way of enforcing HIV-1 "super latency" through a closed chromatin architecture that renders the virus resistant to a range of latency reversing agents.