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RNA-induced epigenetic silencing inhibits HIV-1 reactivation from latency.

Catalina MéndezScott LedgerKathy PetoumenosChantelle L AhlenstielAnthony D Kelleher
Published in: Retrovirology (2018)
The active maintenance of epigenetic silencing by shRNAs acting on the HIV-1 LTR impedes HIV-1 reactivation from latency. Our "block and lock" approach constitutes a novel way of enforcing HIV-1 "super latency" through a closed chromatin architecture that renders the virus resistant to a range of latency reversing agents.
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