New Enhancing MRI Lesions Associate with IL-17, Neutrophil Degranulation and Integrin Microparticles: Multi-Omics Combined with Frequent MRI in Multiple Sclerosis.
Zsolt IllesMalene Møller JørgensenRikke BækLisa-Marie BenteJørgen T LauridsenKirsten H HyrlovChristopher AbooJan BaumbachTim KacprowskiFrançois CottonCharles R G GuttmannAllan StensballePublished in: Biomedicines (2023)
Combination of serial frequent MRI with proteome, neuroinflammation markers, and protein array data of EVs enabled assessment of temporal changes in inflammation and endothelial dysfunction in RMS related to the evolution of new and enhancing lesions. Particularly, the Th17 pathway and IL-1β clustered and correlated with new lesions and Gd enhancement, indicating their importance in BBB disruption and initiating acute brain inflammation in MS. In addition to the Th17 pathway, abundant protein changes between MRI activity groups suggested the role of EVs and the coagulation system along with innate immune responses including acute phase proteins, complement components, and neutrophil degranulation.
Keyphrases
- multiple sclerosis
- contrast enhanced
- immune response
- magnetic resonance imaging
- diffusion weighted imaging
- oxidative stress
- traumatic brain injury
- protein protein
- mass spectrometry
- blood brain barrier
- amino acid
- single cell
- machine learning
- electronic health record
- ms ms
- drug induced
- cerebral ischemia
- high throughput
- cognitive impairment
- binding protein
- dendritic cells
- intensive care unit
- respiratory failure
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- subarachnoid hemorrhage