TIPRL1 and its ATM-dependent phosphorylation promote radiotherapy resistance in head and neck cancer.

Célie CokelaereRüveyda DokEmanuela E CortesiPeihua ZhaoAnna A Sablina Sandra Nuyts Rita Derua Veerle Janssens

Published in: Cellular oncology (Dordrecht) (2023)

Our findings underscore a clinically relevant role for TIPRL1 and its ATM-dependent phosphorylation in RT resistance through modulation of the DDR, highlighting its potential as a new HNSCC predictive marker and therapeutic target.

Keyphrases

dna damage
dna repair
dna damage response
protein kinase
early stage
radiation therapy
locally advanced