Alterations of Brain Metabolites in Adults With HIV: A Systematic Meta-analysis of Magnetic Resonance Spectroscopy Studies.
Sophia DahmaniNicholas KalissAshley Skye VanMeterDavid J MooreRonald J EllisXiong JiangPublished in: Neurology (2021)
The BG are the primary region affected during early infection. cART is successful in partially controlling neuroinflammation (global mI and Cho normalization). However, neuronal dysfunction (NAA reductions) and neuroinflammation (mI and Cho elevations) persist and contribute to cognitive impairment in chronic PWH. Novel compounds targeting NAA signal pathways, along with better neuroinflammation control, may help to reduce cognitive impairment in PWH.
Keyphrases
- cognitive impairment
- systematic review
- cerebral ischemia
- case control
- antiretroviral therapy
- hiv positive
- human immunodeficiency virus
- hiv testing
- meta analyses
- hiv aids
- lipopolysaccharide induced
- ms ms
- traumatic brain injury
- lps induced
- men who have sex with men
- resting state
- subarachnoid hemorrhage
- blood brain barrier
- white matter
- multiple sclerosis
- functional connectivity
- drug delivery