Login / Signup

Aortic Stress Activates an Adaptive Program in Thoracic Aortic Smooth Muscle Cells That Maintains Aortic Strength and Protects Against Aneurysm and Dissection in Mice.

Chen ZhangYanming LiAbhishek ShankarYang LiKimberly R RebelloPingping RenWei LuoLin ZhangHong S Lu (吕红)Lisa A CassisJoseph S CoselliAlan DaughertyScott A LeMaireYing H Shen
Published in: Arteriosclerosis, thrombosis, and vascular biology (2022)
Aortic stress triggers the systemic epigenetic induction of an adaptive response (eg, wound healing, proliferation, matrix organization) in thoracic aortic SMCs that depends on functional biomechanical signal transduction (eg, YAP signaling). Our study highlights the importance of the adaptive response in maintaining aortic homeostasis and preventing AAD in mice.
Keyphrases