Pepsinogen C Interacts with IQGAP1 to Inhibit the Metastasis of Gastric Cancer Cells by Suppressing Rho-GTPase Pathway.

Hanxi DingYingnan LiuXiaodong LuAo-Ran LiuQian XuYuan Yuan

Published in: Cancers (2024)

PGC may act as a tumor suppressor in the development and metastasis of GC. PGC can downregulate its interacting protein IQGAP1 and inhibit the Rho-GTPase pathway, thereby participating in the inhibition of GC cell migration and invasion.

Keyphrases

protein kinase
skeletal muscle
single cell
binding protein
smooth muscle
gas chromatography
mesenchymal stem cells
high resolution