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Sterilizing immunity: New opportunities for rational TB vaccine design.

Alan SherJoanne L Flynn
Published in: The Journal of experimental medicine (2021)
Recent studies have revealed situations of high-level naturally acquired and vaccine-induced immunity against Mycobacterium tuberculosis in animal models along with examples of significantly protective immunization in humans. These discoveries offer immunologists new opportunities to define effector mechanisms that when triggered by appropriately engineered vaccines could end TB's deadly reign.
Keyphrases
  • mycobacterium tuberculosis
  • pulmonary tuberculosis
  • high glucose
  • diabetic rats
  • dendritic cells
  • single cell
  • regulatory t cells
  • case control
  • immune response