Interaction between Genetic Risk Scores for reduced pulmonary function and smoking, asthma and endotoxin.

Sinjini SikdarAnnah B WyssMi Kyeong LeeThanh T HoangMarie RichardsLaura E Beane FreemanChristine ParksPeter S ThorneJohn L HankinsonDavid M UmbachAlison Motsinger-ReifStephanie J London

Published in: Thorax (2021)

Evaluation of interactions using GRSs supports a greater impact of increased genetic susceptibility on reduced pulmonary function in the presence of smoking or asthma.

Keyphrases

chronic obstructive pulmonary disease
lung function
smoking cessation
genome wide
allergic rhinitis
copy number
gene expression
dna methylation