Durability of immune responses after boosting in Ad26.COV2.S-primed healthcare workers.
Roos S G SablerollesWim J R RietdijkAbraham GoorhuisDouwe F PostmaLeo G VisserKatharina S SchmitzDaryl GeersSusanne BogersEva van HarenMarion P G KoopmansVirgil A S H DalmNeeltje A KootstraAnke L W HuckriedeRenate AkkermanMartin BeukemaMelvin LafeberDebbie van BaarleRory D de VriesP Hugo M van der KuyCorine H GeurtsvanKesselPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
The emergence of SARS-CoV-2 variants raised questions regarding the durability of immune responses after homologous or heterologous booster vaccination after Ad26.COV2.S priming. We found that SARS-CoV-2-specific binding antibodies, neutralizing antibodies and T-cells are detectable 5 months after boosting, although waning of antibodies and limited cross-reactivity with Omicron BA.1 was observed.