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Tumour epithelial and stromal characteristics of hepatocellular carcinomas with abundant fibrous stroma: fibrolamellar versus scirrhous hepatocellular carcinoma.

Young-Joo KimHyungjin RheeJeong Eun YooVenancio A F AlvesGi Jeong KimHye Min KimPaulo HermanAline ChagasHaeryoung KimYoung Nyun Park
Published in: Histopathology (2017)
S-HCC and FL-HCC are subtypes of HCC with extensive fibrosis, and the nature of the fibrous stroma differs between them. While the stroma of FL-HCC is composed of dense lamellated collagenous bands with sparse cellular components, S-HCC demonstrates more abundant CAF and tumour-infiltrating macrophages and stemness-related marker expression, suggesting the presence of a complex tumour microenvironment that may influence the aggressive behaviour of S-HCCs.
Keyphrases
  • stem cells
  • epithelial mesenchymal transition
  • high grade
  • signaling pathway