Valproate Reverses Mania-Like Behavior of Clock delta19 Mouse and Alters Monoamine Neurotransmitters Metabolism in the Hippocampus.
Shasha LiuJinxue WeiRongjun NiTianhao GaoPeiyan NiLiansheng ZhaoXiyu DuanXiaohong MaPak C ShamTao LiPublished in: Neuropsychiatric disease and treatment (2021)
Our results indicated that chronic VPA treatment can reverse the mania-like behaviors of the Clock delta19 mouse and further consolidate the validity of the Clock delta19 mouse as a model of BD. Monoamine neurotransmitters and their metabolites in the hippocampus are partly regulated by mutation of the Clock gene or VPA treatment.